Cardiovascular disease-wide association study to investigate shared genetics with peak oxygen uptake
نویسندگان
چکیده
Abstract Introduction Cardiorespiratory fitness, measured as peak oxygen uptake (VO2peak), is a strong predictor of cardiovascular disease (CVD) morbidity and mortality estimated to have large genetic component (∼60%). However, the determinants are yet be established. Our research group recently identified novel variants associated with directly VO2peak. Interestingly, most were specific females. Looking into pleiotropy between VO2peak CVD can help elucidate biological mechanisms explaining link this fitness related trait disease, potentially identify new therapeutic targets. Purpose The association study aims investigate if found in women any phenotypes. Methods 34,188 female participants genotype data from Trøndelag Health Study (HUNT) included study. ICD-coded hospital was collected on each participant ICD codes mapped Phecodes, resulting 100 disease-specific 26 single nucleotide polymorphisms (SNPs) previously (p<5e-6) analyses, all common (minor allele frequency ≥1%). Each tested for phenotypes using logistic mixed model implemented SAIGE. analysis adjusted birthyear ten principal components ancestry. Benjamini-Hochberg false discovery rate (FDR) procedure controlling FDR at 0.05 used correct number SNPs Results After testing phenotypes, 133 SNP-phenotype associations nominally significant (p<0.05). rs17066736 myocarditis had lowest p-value (1.7e-4). Among other pairs ischemic heart cardiac conduction disorders, failure, cerebrovascular diseases arteries veins. when adjusting multiple testing, none reached overall statistical significance. Conclusions findings showed no statistically women. role inborn prediction (in women) needs further assessment. Funding Acknowledgement Type funding sources: Other. Main source(s): NTNU biotechnology
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ژورنال
عنوان ژورنال: European Heart Journal
سال: 2022
ISSN: ['2634-3916']
DOI: https://doi.org/10.1093/eurheartj/ehac544.2264